1
00:00:01,669 --> 00:00:04,049
- [Voiceover] There are several
different organic molecules

2
00:00:04,049 --> 00:00:06,429
you'll find within living organisms.

3
00:00:06,429 --> 00:00:09,877
Carbon is probably one of
the more important ones.

4
00:00:09,877 --> 00:00:12,629
I mean, the others are very
important, don't get me wrong,

5
00:00:12,629 --> 00:00:15,029
but carbon, you a lot of
times have heard of humans

6
00:00:15,029 --> 00:00:17,362
as a carbon-based life form.

7
00:00:18,768 --> 00:00:20,207
Pretty much carbon is the building block

8
00:00:20,207 --> 00:00:22,587
of all living things.

9
00:00:22,587 --> 00:00:24,062
It's about 18% of our body weight.

10
00:00:24,062 --> 00:00:25,710
I mean, don't memorize the number.

11
00:00:25,710 --> 00:00:28,090
Depending on the book,
it'll be 16, it'll be 20.

12
00:00:28,090 --> 00:00:29,173
It's a range.

13
00:00:31,980 --> 00:00:36,147
But these macromolecules,
these components, these pieces,

14
00:00:37,135 --> 00:00:41,117
well, carbon is incorporated
to building larger molecules,

15
00:00:41,117 --> 00:00:45,284
things like carbohydrates,
lipids, proteins, nucleic acids.

16
00:00:48,594 --> 00:00:51,677
Well, all these larger macromolecules

17
00:00:52,657 --> 00:00:55,824
have to somehow be made, put together.

18
00:00:56,883 --> 00:00:59,633
One way is dehydration synthesis.

19
00:01:00,831 --> 00:01:03,663
And look at the second term, synthesis.

20
00:01:03,663 --> 00:01:07,112
Well, synthesis means to build or make.

21
00:01:07,112 --> 00:01:09,279
Dehydration, remove water.

22
00:01:11,419 --> 00:01:14,502
So the case of dehydration synthesis,

23
00:01:15,345 --> 00:01:19,512
it's removing basically a
water molecule to form a bond.

24
00:01:21,301 --> 00:01:25,468
You'll end up removing two
hydrogen and one oxygen ions.

25
00:01:28,023 --> 00:01:31,147
What happens, though, is
you need energy to do this.

26
00:01:31,147 --> 00:01:34,230
Energy is required to break the bonds

27
00:01:35,129 --> 00:01:38,333
and release the water molecule.

28
00:01:38,333 --> 00:01:43,175
So you build from the small
subunits to the larger subunits

29
00:01:43,175 --> 00:01:46,170
to eventually the macromolecules,

30
00:01:46,170 --> 00:01:50,337
things like proteins, lipids,
nucleic acids, carbohydrates.

31
00:01:55,365 --> 00:01:57,966
But you don't always want to build.

32
00:01:57,966 --> 00:02:02,064
Sometimes you wanna break
them down, release energy.

33
00:02:02,064 --> 00:02:05,419
One way the body obtains
energy for the cells is

34
00:02:05,419 --> 00:02:07,836
to break down chemical bonds.

35
00:02:10,226 --> 00:02:14,393
The term hydrolysis, well,
you have hydro and then lysis.

36
00:02:16,507 --> 00:02:19,674
Hydro is water, lysis is cut or break.

37
00:02:22,347 --> 00:02:26,514
So hydrolysis means you can
add water to break a bond.

38
00:02:29,289 --> 00:02:32,087
When you add water to break this bond,

39
00:02:32,087 --> 00:02:34,087
you're releasing energy.

40
00:02:36,395 --> 00:02:38,775
So pretty much dehydration synthesis

41
00:02:38,775 --> 00:02:41,192
is the reverse of hydrolysis.

42
00:02:42,118 --> 00:02:46,285
Hydrolysis breaks down,
dehydration synthesis builds up.

43
00:02:48,914 --> 00:02:50,644
So what you're looking
at here is the rough idea

44
00:02:50,644 --> 00:02:54,727
of how hydrolysis and
dehydration synthesis work.

45
00:02:55,741 --> 00:02:57,644
If you start in the top right,

46
00:02:57,644 --> 00:03:01,417
notice there is a highlighted
H, then a non-highlighted O

47
00:03:01,417 --> 00:03:04,000
then another OH on their side.

48
00:03:04,000 --> 00:03:07,030
What ends up happening is
if you take that molecule

49
00:03:07,030 --> 00:03:10,478
plus the one in the
top left, you get again

50
00:03:10,478 --> 00:03:13,478
a highlighted OH now and another OH.

51
00:03:14,426 --> 00:03:16,968
By putting energy in the right side

52
00:03:16,968 --> 00:03:21,856
you add energy in and you
take out a water molecule.

53
00:03:21,856 --> 00:03:25,523
You form a bond between
these two molecules.

54
00:03:26,698 --> 00:03:29,693
But if now you add water
back in to the left side

55
00:03:29,693 --> 00:03:33,141
hydrolysis, you add water back in,

56
00:03:33,141 --> 00:03:35,974
it breaks a bond releasing energy.

57
00:03:38,029 --> 00:03:40,037
So it all depends on
you trying to build up

58
00:03:40,037 --> 00:03:43,704
larger molecules or
break them down smaller.

59
00:03:45,146 --> 00:03:48,629
Dehydration synthesis builds them up

60
00:03:48,629 --> 00:03:51,712
and then hydrolysis breaks them down.

61
00:03:53,877 --> 00:03:56,512
So let's look at
carbohydrates to start with.

62
00:03:56,512 --> 00:03:58,103
You might have heard of carbohydrates as

63
00:03:58,103 --> 00:04:00,738
a fast energy source,
something that you want

64
00:04:00,738 --> 00:04:02,421
to eat right before a sporting event

65
00:04:02,421 --> 00:04:04,976
to get some high energy.

66
00:04:04,976 --> 00:04:06,706
Well the general formula is

67
00:04:06,706 --> 00:04:09,206
C subscript n H2O subscript n.

68
00:04:12,778 --> 00:04:15,940
What that basically means is if there are

69
00:04:15,940 --> 00:04:18,357
six carbon so C subscript six

70
00:04:19,816 --> 00:04:22,733
there are also six H2O equivalents,

71
00:04:25,040 --> 00:04:27,095
so the Ns are the same.

72
00:04:27,095 --> 00:04:29,696
So you have for every one carbon you have

73
00:04:29,696 --> 00:04:32,113
two hydrogens, to one oxygen.

74
00:04:33,701 --> 00:04:35,919
Now you have smaller
types of carbohydrates

75
00:04:35,919 --> 00:04:39,193
called monosaccharides, you
might have heard of them

76
00:04:39,193 --> 00:04:43,041
or their simpler term
called simple sugars.

77
00:04:43,041 --> 00:04:45,958
Mono means one, saccharides a ring.

78
00:04:46,861 --> 00:04:49,392
So simple sugars are one ring.

79
00:04:49,392 --> 00:04:53,095
Things like glucose, very
common sugar in your body.

80
00:04:53,095 --> 00:04:56,512
Fructose, galactose, ribose, deoxyribose,

81
00:04:59,910 --> 00:05:03,410
and those last two ribose and deoxyribose.

82
00:05:04,287 --> 00:05:06,620
Deoxyribose is found in DNA,

83
00:05:10,117 --> 00:05:11,117
ribose, RNA.

84
00:05:15,376 --> 00:05:17,025
Well if you take these monosaccharides

85
00:05:17,025 --> 00:05:18,337
and start putting them
together and building

86
00:05:18,337 --> 00:05:22,145
larger and larger, you
can make monosaccharides

87
00:05:22,145 --> 00:05:25,965
linking together to make disaccharides,

88
00:05:25,965 --> 00:05:28,229
di just means two.

89
00:05:28,229 --> 00:05:31,967
So you take two
monosaccharides they go through

90
00:05:31,967 --> 00:05:35,496
dehydration synthesis, hold
that water molecule out,

91
00:05:35,496 --> 00:05:37,668
then you get a disaccharide

92
00:05:37,668 --> 00:05:41,197
two monosaccharides bound together.

93
00:05:41,197 --> 00:05:44,610
You can keep adding
more and more and more,

94
00:05:44,610 --> 00:05:47,687
monosaccharides onto its chain.

95
00:05:47,687 --> 00:05:49,336
Just every one you add has to

96
00:05:49,336 --> 00:05:52,086
go through dehydration synthesis.

97
00:05:53,689 --> 00:05:56,441
So sucrose, you may heard of that,

98
00:05:56,441 --> 00:05:59,858
that's glucose and fructose put together.

99
00:06:01,250 --> 00:06:05,167
Maltose, is two glucose
molecules put together.

100
00:06:07,029 --> 00:06:11,029
And lactose, glucose and
galactose put together.

101
00:06:12,079 --> 00:06:14,633
Where do you find lactose anyway?

102
00:06:14,633 --> 00:06:19,115
Yeah it's in dairy, milks,
cheeses, ice creams, yogurts.

103
00:06:19,115 --> 00:06:22,725
So for instance if
someone's lactose intolerant

104
00:06:22,725 --> 00:06:26,057
the problem is they
cannot take that lactose

105
00:06:26,057 --> 00:06:30,284
disaccharide and very easily break it down

106
00:06:30,284 --> 00:06:33,163
into glucose and galactose.

107
00:06:33,163 --> 00:06:36,085
They're either missing or
they don't have enough of

108
00:06:36,085 --> 00:06:39,085
the enzyme that breaks down lactose.

109
00:06:40,149 --> 00:06:43,342
If you're curious the enzyme
is called lactase by the way.

110
00:06:43,342 --> 00:06:45,931
Just switch the O to an
A, lactase is the enzyme

111
00:06:45,931 --> 00:06:48,014
that breaks down lactose.

112
00:06:50,192 --> 00:06:52,572
So here is your ribose and deoxyribose

113
00:06:52,572 --> 00:06:54,383
so they're both pretty much the same.

114
00:06:54,383 --> 00:06:58,655
Five-carbon monosaccharides
the difference comes

115
00:06:58,655 --> 00:07:01,523
into play though when you start looking

116
00:07:01,523 --> 00:07:03,606
at the number of oxygens.

117
00:07:05,122 --> 00:07:08,448
Deoxy means you've lost an oxygen.

118
00:07:08,448 --> 00:07:12,964
So look towards the bottom
right of deoxyribose.

119
00:07:12,964 --> 00:07:14,694
You'll see the bottom line has OH

120
00:07:14,694 --> 00:07:16,784
then next to it just an H.

121
00:07:16,784 --> 00:07:20,367
But in ribose both the
bottom ones are OHs,

122
00:07:21,300 --> 00:07:23,300
there's your difference.

123
00:07:25,375 --> 00:07:27,221
To show a little more of how
things are coming together

124
00:07:27,221 --> 00:07:31,076
or breaking apart, glucose plus fructose

125
00:07:31,076 --> 00:07:33,258
go through dehydration synthesis,

126
00:07:33,258 --> 00:07:35,511
take that water molecule out,

127
00:07:35,511 --> 00:07:37,844
form a bond you get sucrose.

128
00:07:39,238 --> 00:07:41,339
Now don't worry about
memorizing all these formulas

129
00:07:41,339 --> 00:07:43,150
it's not that important.

130
00:07:43,150 --> 00:07:44,253
What's more important is knowing

131
00:07:44,253 --> 00:07:46,761
glucose and fructose are monosaccharides,

132
00:07:46,761 --> 00:07:49,060
sucrose disaccharide.

133
00:07:49,060 --> 00:07:53,367
Carbohydrates are ring shaped,
or roughly ring shaped.

134
00:07:53,367 --> 00:07:55,886
They have this one to two one ratio.

135
00:07:55,886 --> 00:07:57,523
You're not gonna have to draw out sucrose,

136
00:07:57,523 --> 00:08:01,023
or draw out glucose, or draw out fructose.

137
00:08:03,189 --> 00:08:06,091
Polysaccharides, well we went through

138
00:08:06,091 --> 00:08:08,797
monosaccharides, one ring.

139
00:08:08,797 --> 00:08:11,386
Disaccharides, two rings.

140
00:08:11,386 --> 00:08:14,386
Now polysaccharides have many rings.

141
00:08:15,403 --> 00:08:17,945
I put thousands together
here but it could be

142
00:08:17,945 --> 00:08:19,547
hundreds it could be thousands,

143
00:08:19,547 --> 00:08:21,541
it could just keep going, going.

144
00:08:21,541 --> 00:08:24,629
These are huge groupings
of monosaccharides

145
00:08:24,629 --> 00:08:26,296
all bonded together.

146
00:08:29,854 --> 00:08:33,883
Starch is a perfect example
of a polysaccharide.

147
00:08:33,883 --> 00:08:37,883
Starch is how a lot of
plants will store energy.

148
00:08:38,852 --> 00:08:42,996
The plants will take the
individual monosaccharides

149
00:08:42,996 --> 00:08:47,163
and then to start to bind
them together to make starch.

150
00:08:48,755 --> 00:08:53,155
Glycogen is how us as
animals store energy,

151
00:08:53,155 --> 00:08:54,955
it's one way at least.

152
00:08:54,955 --> 00:08:58,403
Glycogen is just a whole series, a mess,

153
00:08:58,403 --> 00:09:01,403
of glucose molecules bound together.

154
00:09:03,198 --> 00:09:04,788
Now the reason it's stored energy is

155
00:09:04,788 --> 00:09:07,038
every bond contains energy.

156
00:09:08,908 --> 00:09:12,437
So anytime you break a
bond you release energy.

157
00:09:12,437 --> 00:09:15,937
The glucose molecule also contains energy.

158
00:09:19,014 --> 00:09:22,102
Cellulose another polysaccharide,

159
00:09:22,102 --> 00:09:25,376
it's indigestible you cannot digest it.

160
00:09:25,376 --> 00:09:27,605
You can chew it up as much as you want,

161
00:09:27,605 --> 00:09:30,682
it still comes out as cellulose.

162
00:09:30,682 --> 00:09:34,954
This is more of a structural
support for plants.

163
00:09:34,954 --> 00:09:39,929
So as a plant-based polysaccharide
get a structural support

164
00:09:39,929 --> 00:09:43,346
something us as humans cannot break down.

165
00:09:46,752 --> 00:09:47,774
So here's what you're seeing with the

166
00:09:47,774 --> 00:09:52,209
dehydration synthesis the
formation of glycogen.

167
00:09:52,209 --> 00:09:55,135
One glucose, second
glucose, they go through

168
00:09:55,135 --> 00:09:57,770
dehydration synthesis to form

169
00:09:57,770 --> 00:10:00,187
the longer chain of glycogen.

170
00:10:01,184 --> 00:10:03,413
Each one of those monosaccharides,

171
00:10:03,413 --> 00:10:06,211
each one of those individual rings,

172
00:10:06,211 --> 00:10:10,294
was bound to the next via
dehydration synthesis.

